Current topics in medicinal chemistry aims to contribute to the growth of scientific. The use of this methodology may help to eliminate some of the drawbacks of anthracycline drugs, e. Together, the results for compounds 79 suggest that while the hydrogenbonding elements of the c3 substituent may be. Aug 12, 2019 these are important examples for the use of this approach with anthracycline antibiotics. To ensure successful pdf conversion during online submission, it is important that the author save a new document based on the template, rather than saving the. The journal publishes reports of experimental results in medicinal chemistry, chemical biology and drug discovery and design, emphasizing new and emerging advances and concepts. Values that are denoted by different letters are signi. Automatically format and order your citations and bibliography in a click. Articles are in the form of communications reporting experimental or theoretical results of special interest. The international scientific journal bioorganic and medicinal chemistry letters presents preliminary experimental or theoretical research results of outstanding significance and timeliness on all aspects of science at the interface of chemistry and biology and on major advances in drug design and development.
Some of the compounds with substituents at the lower nitrogen atom 4857a showed moderate to potent activities in blocking viral entry with ic 50 values below 100 nm in one n r 22. Download citation style files for your favorite reference manager. Characterization of these processes is relevant to both medicinal chemistry and toxicology as it has the potential to reveal novel and chemically interesting strategies for the intracellular generation of biologically active reactive intermediates. Volume 19, issue 15 pages 39814516 1 august 2009 previous volissue. Volume 19, issue pages 335696 1 july 2009 download full issue. The journal publishes reports of experimental results in medicinal chemistry, chemical biology and drug. The journal publishes reports of experimental results in medicinal chemistry, chemical biology and drug discovery and design. Bioorganic and medicinal chemistry letters current research. All clarivate analytics websites use cookies to improve your online experience. Footnotes should appear at the bottom of the appropriate page and be indicated by the following symbols. Discovery, synthesis and in combo studies of a tetrazole analogue. Author guidelines current topics in medicinal chemistry. This demonstrates that the relative potency of inhibitors can be extrapolated from. Copyright letter can be downloaded from the journals web site.
Prototyping kinase inhibitorcytotoxin anticancer mutual prodrugs activated by tumour hypoxia. Our policy towards the use of cookies all clarivate analytics websites use cookies to improve your online experience. Mass spectra showing molecular ions of 5ohp obtained from the oxidation of propranolol with aap 1 u m1, 0. Submit to journal directly or download in pdf, ms word or latex. Journal articles books book chapters reports web pages. Download formatted paper in docx and latex formats. Abstracts of papers, part 2, 212th national meeting of the american chemical society, orlando, fl, aug 25a 29, 1996. Tables all tables should be cited in the text, and. They were placed on your computer when you launched this website.
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